ABSTRACT
The complement system is an important component of the innate immune system, and the occurrence of rheumatoid arthritis, autoimmune hemolytic anemia, COVID-19 and other diseases is closely related to abnormalities of the complement system. At present, most of the complement inhibitors commonly used in clinical practice are chemical synthetic drugs, which are poorly selective, and long-term use can easily lead to a decrease in the body's immune ability. The anti-complement active ingredients from natural products are less toxic and easy to be digested and absorbed by the body, among which the anti-complement active substances of microbial sources have unique advantages and application potential, which can be quickly discovered and identified by genome mining, and use metabolic engineering to modify and optimize mass production, but the relevant research is still in the preliminary research and development stage. This review summarizes the clinical application of the more common complement inhibitors at home and abroad in recent years, and discusses the research and development progress of anti-complement active substances of microbial origin, in order to provide a reference for the clinical research of complement inhibitors and the development of new anti-complement active substances of natural sources.